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3.6 Melanogenesis reduction Ultraviolet radiation stimulates melanogenesis through activation of the microphthalmia-associated transcription factor (MITF)-regulated pathway, promoting tyrosinase (TYR)-dependent melanin synthesis in melanosomes to protect against DNA damage, while excessive production leads to hyperpigmentation disorders (Kim et al., 2021)

The skin changes are not dramatic at 8 weeks but become clinically visible at the 12 to 16-week mark in most patients

299 Poor diets or metabolic conditions can lead to independent atherosclerosis risk factors such as increased ceramide levels